Association between single nucleotide polymorphisms rs2200733 and rs10033464 at chromosome 4q25 and thyrotoxic atrial fibrillation

Background. Thyrotoxic atrial fibrillation (TAF) genesis does not exclude a genetic component due to the difference in thyroid hormones effects on cardiovascular system similar patients. According genomewide association studies (GWAS), first locus associated with non-thyrotoxic (AF) was 4q25, and single-nucleotide polymorphisms it identified as risk factors for AF were rs2200733 rs10033464. Their connection TAF remains unclear. Objective. To investigate possible of two single nucleotide rs10033464 TAF. Design methods. The other thyrotoxic cardiomyopathy manifestations studied examined sample 150 patients Graves’ disease overt thyrotoxicosis, 18.7 % whom had Genotyping preformed using real time PCR. Results. A significant predominance TT genotype both revealed: p=0.038 rs10033464, p<0.001 rs2200733. frequency compared non-TAF participants: 7.4 vs 1.6 17.9 0.8 When assessing genotypes depending presence manifestations, more common ventricular premature beats, p=0.001. Conclusion. at 4q25 is higher incidence extrasystole